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It is important to note that while serum accumulation of MMA and Hcy are sensitive biomarkers of vitamin B 12 deficiency in humans 26 , this is not the case in mice 37,38
The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes
The derived protein structure requires specific storage conditions
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