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B420 is the probiotic strain in the formula, and the published 6-month RCT in 225 overweight and obese adults reported a body fat mass difference of -4.0% versus placebo (P=0.002), a 2.4 cm waist circumference reduction more than placebo, and a daily energy intake reduction of approximately 300 kcal compared to placebo (post-hoc factorial analysis).[9] The trial did not select for GLP-1 users, did not measure constipation as an endpoint, and the available evidence is at the ingredient-level human evidence tier

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GLP-1 RAs were linked to a significantly higher risk for AGA and NSHL at six months (adjusted odds ratios, 1.62 and 1.26, respectively)

In response, herbivores have simultaneously developed countermeasures against plant defense compounds [5]