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10.5 Transformative potential of nanotechnology-enabled redox sensing in cancer Redox-sensitive nanotechnology holds transformative potential for cancer therapy by targeting the distinct oxidative imbalances present in tumor microenvironments

Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved

A well-characterized example is ezatiostat (TLK199)a GSH peptidomimetic moleculedesigned to display enhanced cellular uptake and whose metabolites bind the G-site of GSTP1-1 causing enzyme inhibition

Monnerat G, Seara FAC, Evaristo JAM, Carneiro G, Evaristo GPC, Domont G, et al