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Effective, sometimes
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While SGLT2 inhibitors and GLP-1 receptor agonists carry a low hypoglycemia risk when used as monotherapy in type 2 diabetes, their additive glucose-lowering effects can precipitate hypoglycemia when used in combination with insulin
Males were also initially excluded since there were concerns about the potential for testicular toxicity at the outset of the trial that emanated from the aforementioned toxicology study in Sprague Dawley rats (see Supplementary Results for complete details of this preclinical study)
The Rybelsus rating gap is the most consistent finding
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