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Stress Reporter Assay of AQ-QI and DEAQ-QI To identify the stress response pathways upon AQ-QI and DEAQ-QI exposure, oxidative stress response (SRXN1-GFP), ER stress response (CHOP-GFP), inflammation response (ICAM1-GFP), and DNA damage response (p21-GFP) pathways were measured with a high-content image-based BAC-GFP stress responses reporter assay ( HepG2-based reporter cells were generated by Bacterial Artificial Chromosome tagging as described previously ( 4 per well in 0.1 mL DMEM, treated subsequently as described above
A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis
QJ, KB and YYB recruited the patients, WZB, ZJJ, CYJ, QCP, and SLY conducted the clinical study
LC-HRMS/MS High-resolution mass spectrometry provides mass accuracy at parts-per-million (ppm) levels
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