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Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway
Doxycycline inhibits TGF-beta1-induced extracellular matrix production in nasal polyp-derived fibroblasts
Prior studies have demonstrated superior weight-loss efficacy with higher doses of both agents, but direct comparisons have been limited and often restricted to specific dose combinations or populations without diabetes
Those with pre-existing chronic liver disease warrant closer surveillance, though semaglutide is not contraindicated in compensated liver disease
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