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Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials
Notably, while total FOXO4 protein levels remained consistent between young and elderly men, a striking age-dependent shift in its subcellular localization was observed: FOXO4 predominantly resided in the cytoplasm in young Leydig cells but translocated to the nucleus in aged cells
5 CHAC1 involvement in non-malignant diseases Oxidative stress, resulting from the excessive accumulation of ROS and reactive nitrogen species (RNS), plays a critical role in the pathogenesis of various non-malignant diseases
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