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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically
Validation of the Toronto Psoriatic Arthritis Screen Version 2 (ToPAS 2)
It was demonstrated in in vitro experiments that OGD effectively induced the death of ADSCs
Hes used the subcutaneous route as well (source)
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