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In the STEP-1 semaglutide trial, roughly 39% of the weight lost was lean mass in the DEXA substudy ( Wilding et al., NEJM 2021 )
Medications like Ozempic and Wegovy use this mechanism to support both blood sugar regulation and weight management
AND NOW FOR THE CONTROVERSY: DOES IGF-1 DECREASE LONGEVITY
Reduced functional vitamin B12 deficiency is associated with lower activity of the Krebs cycle enzyme, Aconitase, which in turn results in lower energy entering Krebs cycle, higher urinary citrate, and lower Mini Mental score
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