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Newer ERAs have since been designed that preferentially target endothelin A receptors, associated with inflammation and podocytopathy, over endothelin B receptors, associated with vasodilation and natriuresis [74]
More serious but less common side effects include pancreatitis, gallbladder disease, and worsening of diabetic eye disease
These bundled prices may appear higher than medication-only prices but can represent good value when the full cost of treatment is considered
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