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One of the most debilitating and defining hallmarks of ME/CFS and Long COVID is post-exertional malaise (PEM), a severe, disproportionate exacerbation of symptoms following even minor physical, cognitive, or emotional exertion

The investigators reported partial restoration of the circadian melatonin rhythm in elderly subjects following the epithalamin course, with measurable but incomplete return toward younger-adult patterns of nocturnal melatonin secretion [2]

Data values for blood serum measures at this one data point represent the mean of 5 imputations using a linear regression imputation model

In human clinical trials, individuals ingesting ME-3 for two weeks gained a remarkable 49% increase in the ratio between reduced to oxidized glutathione