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These contraindications are based on established clinical and pharmacological concerns
Gregory A
First , for the purposes of determining whether the concentration of a Section 4 Substance is high enough to amount to an anti-doping rule violation, Anti-Doping Organisations ( ADOs ) rely on the concentration estimates reported by the relevant WADA-accredited laboratories, rather than a Validated Quantification Procedure as used to assess the concentration of Threshold Substances
In phase II clinical trial (NCT03287245), Idasanutlin was given to 27 patients with HU-resistant orintolerant PV
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