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When administered to patients with NASH for 12 weeks, aldafermin (up to 6 mg daily) reduced liver fat content by up to 60% relative to baseline, reduced ALT by about 50%, and decreased Pro-C3 by about 2025% (306)

Clinical data shows an average regain of 5.63 kilograms after stopping semaglutide, with most patients returning to near-baseline weight by 18 months post-discontinuation

A study by the UK Prospective Diabetes Study Group has shown that long-term intensive glucose control could reduce mortality rate, possibly due to the potential benefit of these medications [37]