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This should be used in conjunction with other known methods of combating fatigue, such as losing weight, reducing stress, drinking less alcohol, and trying to partake in more physical activities
Andrographolide inhibits CYP3A4 activity by binding and antagonizing PXR function, and is a potential CYP3A4 inhibitor that may have clinical significance (Ooi et al., 2011)
doi: 10.3389/fmed.2021.649408
(6) M H Rasmussen, J Frystyk, T Andersen, L Breum, et al (1994) The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone Metabolism, 1994 Mar, Volume 43 (Issue 3), Pages 315-9
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