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Available online at: www.fda.gov/regulatory-information/search-fda-guidance-documents/testicular-toxicity-evaluation-during-drug-development (Accessed December 19, 2024)

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After occlusion of the inferior caval vein, accordingly, BPC 157 counteracts the whole Virchow triad (Vukojevic et al., 2018) and inferior caval vein syndrome (Vukojevic et al., 2018)

This could explain why the activity of rhGPx3 mutant using H 2 O 2 as oxidizing substrate was in the same order of magnitude as that of human native GPx4 (34.8 U/mg) 9 and GPx4 mutant with all Cys converted to Ser (14.0 U/mg) 16 , while it was much lower than that of native GPx4 (64.6 U/mg) and the GPx4 mutant (24.6 U/mg) in the case of using PLPC-OOH as the oxidizing substrate