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CJC-1295 (no DAC) is a tetra-substituted analog of GRF(1-29) that engages the GHRH receptor on anterior-pituitary cells, while Ipamorelin is a pentapeptide agonist of the ghrelin / growth-hormone-secretagogue receptor (GHS-R1a)

The relevant study also found that the 1-year average weight loss of participants (LIR 3.0 mg) was 9.2 kg reporting nausea/vomiting episodes, while that of participants without nausea/vomiting was 6.3 kg

4) Minimal Cost Impact: Even at $400,000/kg, the drug cost per dose is under $1, making the higher raw material cost acceptable in the broader economics of injectable drug products