In a pilot study in Thailand, Sangsuwan and Asawanonda tested the influence of daily intake of oral collagen (5 g) for 4 weeks on skin elasticity, especially in sun-exposed areas, in a randomized, double-blind, placebo-controlled trial (in a total of 36 women, aged 4060 years, where one-half of the participants were in the treatment group [ n = 18] or the placebo group [ n = 18]) [39]
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However, the outcomes of ROS-protein interactions are complex and dependent on several contextual factors including the concentration and type of ROS, the cell type, and the specific signaling pathways that are altered
The role of epigenetic change in autism spectrum disorders