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doi:10.1042/BST0330811
B12 supports red blood cell production and methylation pathways that come under load during rapid fat loss
To reduce reactions: Allow the solution to warm to room temperature for 5 to 10 minutes before injecting (cold solution stings more) Inject slowly over 5 to 10 seconds rather than pushing the plunger quickly Apply gentle pressure with a cotton ball after withdrawing the needle (do not rub) Consider using a higher concentration to reduce injection volume If injection site reactions persist , switching to a different anatomical site or adjusting your reconstitution concentration may help
However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo
