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6 Interaction with Voltage Gated Calcium Channels Voltage Gated Calcium Channels (VGCCs), also termed Voltage-Dependent Calcium Channels (VDCCs), are widely expressed in the CNS of humans and other mammalian and play a critical role in the regulation of synaptic transmission, phosphorylation/dephosphorylation of protein, gene transcription, as well as perform various other functions including the survival and death of the cell and adaptive responses to the synaptic activity (Xu and Tang, 2018)

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This raises the interesting question of whether vaccination prior to the first influenza infection can be tailored to shape a more broadly protective immune response throughout life [125]