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Both approaches can produce similar synergistic metabolic effects, but offer different advantages: Dual agonists (tirzepatide): Single injection, simplified logistics, pre-optimized GIP/GLP-1 ratio Selective GIP agonist + GLP-1 agonist combination: Flexible dosing of each component, ability to adjust individual peptide ratios, research selectivity for investigating each hormone's contribution COMBINATION FLEXIBILITY AND PERSONALIZED DOSING Separate cagrilintide and semaglutide administration allows researchers to adjust each component independently