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Hypoxic conditions can also lead to a phenomenon known as DPP-4 shedding whereby transmembrane DPP-4 is cleaved from the membrane and released into the circulation in a soluble form
Consequently, these patients respond poorly to microvascular decompression (MVD) and achieve significantly lower success rates than typical TN from radiation procedures such as Gamma Knife
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Research has explored its interactions with extracellular matrix remodeling, collagen synthesis pathways, and cellular defense mechanisms linked to tissue maintenance and regeneration
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