muscle loss on glp 1 Do GLP-1 Drugs Cause Too Much Loss? What You Need to Know Muscle Loss with GLP-1 Medications:

Research is showing that women are driving much of that demand related to weight loss supportin fact, an August 2025 RAND report found that nearly one in five women ages 50 to 64 now take a GLP-1, with overall usage higher among women than men

This differs from Ozempic, which directly mimics GLP-1 and activates its receptors

Currently, multiple phase 3 trials with oral semaglutide and orforglipron are ongoing for different populations (NCT05803421), while another oral GLP-1 RA (CT-996) is in early phase clinical trials (Table 1)

1 v Death from cardiovascular causes, as confirmed by the event adjudication committee, includes both death from cardiovascular causes and death from undetermined causes adjudicated by that committee