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Insulin gene transcription and translation, as well as the enhancement of glucose-stimulated insulin secretion (insulinotropic effects), are caused by GLP- 1 receptor activation in the beta cell
The drug cleared its safety check and showed no clear benefitand then the company dissolved and the program stopped
Differences between GLP-1 receptor agonists and DPP-4 inhibitors[1] Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM)
TD: Tardive Dyskinesia for total (+) active metabolites for tetrabenazine & deutetrabenazine Schneider et al (2021) Adapted from Diana (2007), Schneider et al (2021) & Cheung & Parmar (2022) References: Aminoff MJ (2024): Pharmacologic Management of Parkinsonism & Other Movement Disorders (Chapter 28)
