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Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)

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Reasons for this include off-target side effects due to lack of target selectivity or inability to demonstrate efficacy due to inappropriate choice of disease or suboptimal trial design 14

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Research in colitis models shows GHK-Cu produces beneficial anti-inflammatory effects, reducing intestinal inflammation and promoting mucosal healing

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Roy et al

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