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While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brains immune system, including microglia and astrocytes (Ferreira et al., 2013)

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[3] [2] In the United States, afamelanotide is indicated for increasing pain-free light exposure in adults with a history of reactions to light (phototoxicity) from erythropoietic protoporphyria

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