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BROOKS BEASTS The record has been shattered
No oral, transdermal, or intranasal formulation of either compound has demonstrated clinically meaningful systemic bioavailability in humans
FIGURE 1 3.2.2 CSD theory Trigeminal afferent activation sets off the pain pathway, which sends information to the TG, the TNC, and finally to the brainstem and cortical structures involved in pain processing, resulting in pain ( Alterations in the concentrations of intracellular and extracellular ions are linked to the production of CSD
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