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Semaglutide is indicated, in combination with a reduced calorie diet and increased physical activity, to reduce excess body weight and maintain weight reduction long term in adults and pediatric patients aged 12 and older with obesity, and in adults with overweight plus at least one weight-related comorbid condition

The FDA labels for weight management formulations explicitly recommend comprehensive lifestyle intervention as part of treatment

PMID: 16539679 Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia

This side effect is relatively unique to retatrutide and may relate to the glucagon receptor component