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The mechanism likely involves GLP-1 receptors in the brain

Hypothalamus, specifically the arcuate nucleus and the dorsal vagal complex in the brain stem, are the most relevant structures involved in this function.1 The role of the arcuate nucleus and the brain stem consists in an integration within signals coming from periphery and recognized in the gut hormones2 (Fig

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95% CI, 1.00 to 1.77) exhibited a significantly elevated risk, whereas dulaglutide did not