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In the STEP UP clinical trial, the 7.2 mg dose produced a mean weight loss of 20.7% at 72 weeks, compared with 17.5% at the previously approved 2.4 mg dose and 2.4% with placebo

Aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, is controlled by retinoic acid and plays a crucial role of aldehyde dehydrogenase enzymes in the survival of dopaminergic neurons by controlling the ALDH1A1 enzyme in PD (103)

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