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If the gap between peak and trough is causing both excess side effects and inadequate efficacy, split dosing addresses both problems simultaneously by flattening the curve in both directions
Increase dose gradually
This medical oversight is essential for safe, effective weight loss
This multi-receptor mechanism distinguishes it from earlier weight-management medicines such as semaglutide (Wegovy) or tirzepatide (Mounjaro), and it also explains why gastrointestinal effects including changes to bowel habits are among the most frequently reported experiences in clinical trials
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