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The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]

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ESCRT-III, in conjunction with associated proteins, facilitates the final split of vesicles and participates in protein deubiquitination

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