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2 Tumor-associated macrophages: an in-depth analysis The traditional belief that tumor-associated macrophages (TAMs) solely originate from bone marrow monocytic progenitors has evolved substantially in recent years ( 2.1 Diversity and classifications of TAM The diverse origins and functional variability of TAMs ( Figure 2 ) pose considerable difficulties for their ontological classification ( Figure 2 2.2 Macrophage polarization states and their distinctive properties Macrophages exhibit remarkable heterogeneity and adaptability, rapidly responding to environmental cues by polarizing into functionally distinct phenotypes

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Clinical use in humans is based on extrapolation from preclinical data, clinical experience, and case reports