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73 This was a multicentre observational cohort study from 170 hospitals across the US that investigated the effects of GLP-1 RAs on clinical outcomes, a composite of HF hospitalisation and all-cause mortality, in 1,024 obese HFpEF patients compared with 796 controls receiving dipeptidyl peptidase inhibitor/sulphonylurea therapy
Protein degradation (proteasome activity, MG-132 assay): IGF-1 LR3 1824% (Akt-mediated FoxO1/3 phosphorylation suppressing Atrogin-1)
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