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Clinical trials provide valuable perspective, but safety arises from candid discussions with a provider and transparent follow-up

Cholesterol esters account for 3040% of the lipid content in HDL, with the majority existing as cholesteryl linoleate, which is vital for HDLs structural and functional roles [77, 89]

Given that IL-22 receptor expression is limited to epithelial cells and not detectable in immune cells [151], this specificity is expected to reduce potential side effects of IL-22 in clinical applications, making it a promising therapeutic target for ALD [153]

Patients should contact their healthcare provider if diarrhea persists beyond 2-4 weeks after reaching a stable dose, as this may indicate inadequate tolerance or an alternative underlying condition requiring investigation