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Results consistently show major reductions in inflammatory markers (IL-6, TNF-alpha, CRP), less pain behavior in animal models, reduced swelling, and better function without the side effects of traditional anti-inflammatory drugs

Patients should prioritize whole foods including lean proteins, non-starchy vegetables, whole grains, and healthy fats

Metformin, SGLT2 inhibitors, insulin, GLP-1 receptor agonists, and dual agonists work through different biological routes

In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]