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The combination has not been formally tested in any published clinical trial as of May 2026
In the circulation, the reduced form of homocysteine results from a direct cellular efflux (Blom, 2000) or from circulating thiolactone hydrolysis by homocysteine thiolactone hydrolase (Jakubowski, 2000b)
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Conversely, H 2 O 2 /O can exert an opposite effect through the AMPK pathway, inhibiting gluconeogenesis while promoting glucose uptake and utilization [177, 178]
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