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A study of 185,066 people with type 2 diabetes found that those taking a GLP-1 receptor agonist had a slightly higher risk of developing diabetic retinopathy but a lower likelihood of serious complications such as vision loss ( JAMA Network Open , Aug

69 Conversely, the extracellular release of decorin (DCN, an extracellular matrix-derived damage-associated signaling proteoglycan), 70 high mobility group box 1 (HMGB1, an architectural DNA-binding factor in the cell nucleus), 71 and nuclear receptor coactivator 4 (NCOA4, a mediator of ferritinophagy) 72,73 may function as damage-associated alarm signals that promote inflammatory responses in the local microenvironment

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