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Formation and Mechanism Long-term UV exposure triggers melanin production to prevent sun damage Oxidative stress due to heat damages skin cells Appearance Face, hands, arms, neck, and feet Distinguishing Features Uneven tanning of the body (Appears only on the exposed areas Freckles or sun spots Often appears with aging Uneven Skin Tone In uneven skin tone, there are no defined dark spots, but general skin dullness or patchy pigmentation

In rare cases, especially with high doses or improper administration, more serious side effects can occur, such as issues affecting the liver or kidneys

These studies demonstrated beneficial increases in multiple immune functions, such as a significant increase in NK cell activity, cytokine response, and immune modulation.* The latest study is in the process of peer-review prior to publication

421 However, neurophysiological measurements, molecular pathways, and pathological findings do not fully explain the presence of neuropathic pain in diabetes