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NEJM January 2015 Population: Emergency department patients (n=27) between the ages of 18 and 95 who were on ACE-I and exhibited angioedema affecting the upper aerodigestive tract after excluding those with other causes of angioedema, Excluded: History of angioedema before ACE-I use, acute urticaria, acute myocardial ischemia, unstable angina, acute heart failure (NYHA class III-IV), or pregnant or lactating

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