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In a PPND study in rats, administration of 0, 15, 35, and 60 mg/kg/day ritonavir from GD 6 through PND 20 resulted in no developmental toxicity, at ritonavir systemic exposures greater than 10 times the exposure at the approved human dose of PAXLOVID
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The more ApoB particles in circulation, and the smaller they are, the deeper they penetrate and the more fuel they deliver to an already active fire
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