Whilst tirzepatide exhibits relatively consistent pharmacokinetics across diverse patient populations, several factors warrant consideration as they may theoretically influence drug exposure, though clinical significance varies
Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
274 A subsequent phase III clinical trial (NCT06183931) will assess its efficacy on the basis of all-cause mortality and cardiovascular events
According to the same survey, Awareness of GLP-1 drugs has increased in the past year, with about one-third (32%) of adults now saying they have heard a lot about these drugs, up from 19% in July 2023. Fifty-four percent of people who took a GLP drug said it was difficult to afford and it is often reported that, although doctors recommend staying on these drugs for a lifetime, many abandon them after a year
