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The medication works by mimicking a hormone called GLP-1 (glucagon-like peptide-1) that targets areas of the brain involved in regulating appetite and food intake
Current evidence suggests that both mechanismsneurobiological and psychosociallikely contribute to reported mood improvements in semaglutide users
Adults with obesity but without type 2 diabetes treated for 72 weeks achieved mean body weight reductions of 20.2% with tirzepatide versus 13.7% with semaglutide an absolute difference of 6.5 percentage points (95% CI: -8.1 to -4.9
To date, there is no evidence that tirzepatide exacerbates autoimmune thyroid disease or increases thyroid antibody levels in patients with Hashimoto's thyroiditis, though specific studies in this population are limited
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