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For example, in tubular epithelial cells exposed to high glucose, Exendin-4 reduced TGF--induced fibronectin and COL1A1 expression and decreased secretion of the microRNA miR192, which is implicated in kidney fibrosis, pro-fibrotic microRNA-192, a mediator implicated in renal fibrosis [59]
However, for some, these symptoms can become severe enough to disrupt daily life or lead to medication discontinuation
European journal of nutrition
Results for anxiety were similar: Are these potential effects on anxiety and depression caused by the weight loss from GLP-1s
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