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The shift toward chronic disease prevention and improved metabolic health is positioning GLP-1 receptor agonists as a cornerstone of modern obesity treatment strategies Restraint/Challenge Side Effects and High Treatment Costs Pose Adoption Barrier Concerns surrounding the side effects and high cost of GLP-1 receptor agonist therapies pose significant challenges to broader market adoption

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Recent negative outcomes from the pivotal phase 3 EVOKE and EVOKE+ trials, which demonstrated no clinical benefit of oral semaglutide in patients with early AD, have resulted in a notable translational paradox

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