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Interest really took off in 2021 when the FDA approved semaglutide better known as Wegovy for chronic weight management, followed by Zepbound in late 2023
As PBMs adjust their GLP-1 strategies in response to resolved supply constraints, brokers who understand the rebate landscape can help clients negotiate better terms without reducing coverage
While DSIP was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, subsequent studies on the subject have been contradictory
Patients taking oral semaglutide (Rybelsus) should discuss medication scheduling with their provider to ensure optimal absorption of both medications, as both require administration on an empty stomach
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