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GLP-1 agonists primarily act in the gut-brain axis, significantly slowing gastric emptying, promoting satiety, and consequently reducing caloric intake
The TECOS trial showed no difference between the placebo and a sitagliptin group (Table 2) [47,48,49]
[PMID: 5153312] PubMed record related to this compound for laboratory literature review
Lifestyle modification remains fundamental, and patients should be encouraged to maintain healthy eating patterns, regular physical activity, and adequate hydration (individualised to their clinical situation, particularly for those with heart failure or kidney disease)
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