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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months
Eur J Inflammation (2022) 20:116
GHK-Cu (Copper Tripeptide-1) Mechanism of Action GHK-Cu exerts its effects primarily through its ability to bind copper ions, which are crucial for various enzymatic processes, including collagen synthesis, wound repair, and antioxidant defense
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