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These changes were characterized by either an increase in muscle size and density or a reduction in fat content
Pancreatitis : Tirzepatide can, in rare cases, cause inflammation of the pancreas
GLP-1 slows digestion and alters bile secretion
134 The NLRP3 is also upregulated resulting from activated NF-B, and activates caspase 1 which induces cell pyroptosis, a type of programmed cell death characterized by the formation of pores in the plasma membrane, leading to the release of proinflammatory cytokines and subsequent cell lysis 38,135 (Fig
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