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Intriguingly, a recent study has confirmed that GLP-1R acts as a negative co-stimulatory molecule on T cells

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Nanomedicine 12:421430 Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E (2010) Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis-and Alzheimers disease-related animal models despite reported blood-brain barrier disruption

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They are approved for the management of type 2 diabetes

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