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The researchers noted that while drug-induced hypersensitivity reactions, including generalized pruritus and rash, have been documented, this presentation represented a delayed hypersensitivity reaction "characterized by well-defined, recurrent patches at discrete sites, driven by localized immune responses involving drug-specific cytotoxic T cells retained in the skin." Following discontinuation of semaglutide, the patient showed complete resolution of active lesions at 1-month follow-up, with residual postinflammatory hyperpigmentation
Digital twin systems integrate physiological data with computational models to optimize patch application, dose adjustments, and drug absorption
Mechanick JI, Farkouh E
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